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Hot Topics in Pain Management [August 2016] 16 used determined the relation b etween ages and serum total cholesterol levels of patients, the slope and Y-intercept of the linear regression were provided. Fisher's exact test was used to determine w hether the patients with high cholesterol levels have higher possibility to require additional doses of opioids for pain management than those with low cholesterol levels. P values of Fisher's exact test were provided. *,**, and *** were used to indicate a P value lower than 0.05, 0.01, and 0.001 respectively. ADDITIONAL FILES Additional File 1. A list of current patients' information. The records of 282 patients were listed after removing primary information. ID was the reference number provided by the authors for easier accession. "Chol level" represented the serum cholesterol level measured and recorded. "Year" represented when the initial diagnosis of cancer was made. "Initial dose", "stable dose" and "converted dose" represented the initial dose opioid administration, the final dose of opioids used for analysis and the dose when converted to equivalent oxycodone hydrochloride, respectively. The "increased" column, "1" or "0" were used to represented that "stable dose" was higher than "initial dose". If the patient has one or multiple additional measurement of cholesterol during the first month after opioid administration, the cholesterol level with largest difference from initial cholesterol level was selected, recorded in "Chol level with largest difference" column, and normalized to the initial cholesterol level. (XLSX 43 kb) AUTHORS' CONTRIBUTION ZH, DZ, PYL and HHL designed, conceived, and supervised the study. HZ and PYL wrote the manuscript. Other authors collected and analyzed the data. The first three authors, ZH, LL, and LL, contributed equally to the manuscript. All authors read and approved the final manuscript. REFERENCES 1. 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