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ICNS INNOVATIONS IN CLINICAL NEUROSCIENCE March-April 2018 • Volume 15 • Number 3–4
lessons were also found to significantly improve
children's visual and spatial memory.
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IN THE PIPELINE: NEW MIGRAINE
PREVENTION DRUG TO BE STUDIED
FOR SAFET Y AND EFFICAC Y
Amgen is recruiting patients to test their
new drug compound, AMG 301, for migraine
prevention. The drug, which is a monoclonal
antibody, will be tested against a placebo in a
Phase IIa, randomized, double-blind study. The
aim of the study will be to measure how the
drug impacts monthly migraine days from the
start of the study compared to the end.
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PORTABLE DEVICE DETECTS
SEVERE STROKE IN SECONDS WITH
92-PERCENT ACCURAC Y
A new device worn like a visor can detect
emergent large-vessel occlusion in patients
with suspected stroke with 92-percent
accuracy, according to clinical investigators
from the Medical University of South Carolina,
Mount Sinai and the University of Tennessee
Health Sciences Center. In an article published
in the Journal of Neurointerventional Surgery,
the researchers say that early detection allows
patients with large-vessel occlusions to be
routed to a comprehensive stroke center more
quickly.
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NATALIZUMAB AS A TREATMENT FOR
MULTIPLE SCLEROSIS
A study published in Lancet Neurology
reports that natalizumab was not better than
the placebo in reducing disease progression in
patients with secondary progressive multiple
sclerosis (MS), as measured by the Expanded
Disability Status Scale (EDSS) and the Timed 25-
Foot Walk (T25W). The drug did, however, have
positive results in reducing upper-limb disability
progression.
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DO ONLINE MEDICAL RECORDS MAKE
YOU WORRY?
This article discusses the risk of patients
jumping to the wrong conclusions regarding
diagnoses based on initial labeling of their
medical records, which are now federally
required to be accessible by patients.
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BRAIN INJURY MODELING REVEALS
DEEP TRAUMA PATTERNS
New research indicates that some of the
most dangerous brain injuries today don't come
from hitting your head on a hard surface. In fact,
sometimes they come from not hitting your
head on anything. Kaveh Laksari, an assistant
professor of biomedical engineering at the
University of Arizona who has been researching
traumatic brain injury since 2007, published a
paper titled "Mechanistic insights into human
brain impact dynamics through modal analysis"
in the journal Physical Review Letters.
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COULD THIS DRUG HELP THE BRAIN
RECOVER AFTER A STROKE?
A new drug has been shown to improve
movement and dexterity in mice and macaque
monkeys after stroke. Data from these
experiments were published in the journal
Science. The drug was originally tested as a
treatment for patients with Alzheimer's disease.
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BEST PRAC TICES LACKING FOR
MANAGING TRAUMATIC BRAIN
INJURY IN GERIATRIC PATIENTS
When older adults suffer a traumatic
brain injury (TBI), they might benefit from
aggressive treatment and rehabilitation, but
the lack of evidence-based, geriatric-specific
TBI guidelines presents barriers to optimal
care. The need for more clinical research and
prognostic models on TBI in the growing
geriatric population is described in the article
published in the Journal of Neurotrauma.
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CHILDHOOD BRAIN INJURIES COULD
BE LINKED TO ADHD YEARS LATER
Very young patients who suffer a
traumatic brain injury (TBI) were 3.6 times
more likely than the control group to develop
attention deficit hyperactivity disorder
(ADHD), according to results published in
JAMA Pediatrics. The ADHD didn't develop
until up to 6.8 years after the initial injury,
confirming there are long-term effects of
suffering a TBI.
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DEMORALIZATION DISTINC T FROM
DEPRESSION IN PARKINSON'S
DISEASE
Research published in Neurology
found that 18 percent of patients with
Parkinson's disease experience symptoms of
"helplessness, hopelessness, and/or a sense
of failure" that is separate from depression.
A significant percentage of patients with
demoralization did not have depression, and
vice versa.
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