Innovations In Clinical Neuroscience

MAR-APR 2018

A peer-reviewed, evidence-based journal for clinicians in the field of neuroscience

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53 ICNS INNOVATIONS IN CLINICAL NEUROSCIENCE March-April 2018 • Volume 15 • Number 3–4 lessons were also found to significantly improve children's visual and spatial memory. * Full story IN THE PIPELINE: NEW MIGRAINE PREVENTION DRUG TO BE STUDIED FOR SAFET Y AND EFFICAC Y Amgen is recruiting patients to test their new drug compound, AMG 301, for migraine prevention. The drug, which is a monoclonal antibody, will be tested against a placebo in a Phase IIa, randomized, double-blind study. The aim of the study will be to measure how the drug impacts monthly migraine days from the start of the study compared to the end. * Full story PORTABLE DEVICE DETECTS SEVERE STROKE IN SECONDS WITH 92-PERCENT ACCURAC Y A new device worn like a visor can detect emergent large-vessel occlusion in patients with suspected stroke with 92-percent accuracy, according to clinical investigators from the Medical University of South Carolina, Mount Sinai and the University of Tennessee Health Sciences Center. In an article published in the Journal of Neurointerventional Surgery, the researchers say that early detection allows patients with large-vessel occlusions to be routed to a comprehensive stroke center more quickly. * Full story NATALIZUMAB AS A TREATMENT FOR MULTIPLE SCLEROSIS A study published in Lancet Neurology reports that natalizumab was not better than the placebo in reducing disease progression in patients with secondary progressive multiple sclerosis (MS), as measured by the Expanded Disability Status Scale (EDSS) and the Timed 25- Foot Walk (T25W). The drug did, however, have positive results in reducing upper-limb disability progression. * Full story DO ONLINE MEDICAL RECORDS MAKE YOU WORRY? This article discusses the risk of patients jumping to the wrong conclusions regarding diagnoses based on initial labeling of their medical records, which are now federally required to be accessible by patients. * Full story BRAIN INJURY MODELING REVEALS DEEP TRAUMA PATTERNS New research indicates that some of the most dangerous brain injuries today don't come from hitting your head on a hard surface. In fact, sometimes they come from not hitting your head on anything. Kaveh Laksari, an assistant professor of biomedical engineering at the University of Arizona who has been researching traumatic brain injury since 2007, published a paper titled "Mechanistic insights into human brain impact dynamics through modal analysis" in the journal Physical Review Letters. * Full story COULD THIS DRUG HELP THE BRAIN RECOVER AFTER A STROKE? A new drug has been shown to improve movement and dexterity in mice and macaque monkeys after stroke. Data from these experiments were published in the journal Science. The drug was originally tested as a treatment for patients with Alzheimer's disease. * Full story BEST PRAC TICES LACKING FOR MANAGING TRAUMATIC BRAIN INJURY IN GERIATRIC PATIENTS When older adults suffer a traumatic brain injury (TBI), they might benefit from aggressive treatment and rehabilitation, but the lack of evidence-based, geriatric-specific TBI guidelines presents barriers to optimal care. The need for more clinical research and prognostic models on TBI in the growing geriatric population is described in the article published in the Journal of Neurotrauma. * Full story CHILDHOOD BRAIN INJURIES COULD BE LINKED TO ADHD YEARS LATER Very young patients who suffer a traumatic brain injury (TBI) were 3.6 times more likely than the control group to develop attention deficit hyperactivity disorder (ADHD), according to results published in JAMA Pediatrics. The ADHD didn't develop until up to 6.8 years after the initial injury, confirming there are long-term effects of suffering a TBI. * Full story DEMORALIZATION DISTINC T FROM DEPRESSION IN PARKINSON'S DISEASE Research published in Neurology found that 18 percent of patients with Parkinson's disease experience symptoms of "helplessness, hopelessness, and/or a sense of failure" that is separate from depression. A significant percentage of patients with demoralization did not have depression, and vice versa. * Full story ICNS N E W S & T R E N D S

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