Innovations In Clinical Neuroscience

MAR-APR 2018

A peer-reviewed, evidence-based journal for clinicians in the field of neuroscience

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52 ICNS INNOVATIONS IN CLINICAL NEUROSCIENCE March-April 2018 • Volume 15 • Number 3–4 NEW BRAIN MAPS WITH UNMATCHED DETAIL COULD CHANGE NEUROSCIENCE A neuroscientist was able to develop a technique called multiplexed analysis of projections by sequencing (MAPseq) that creates a 3-D visualization of a brain's neuron connections. Initial research on the technique was published in the journal Nature, but the neuroscientist, Dr. Tony Zador, says he hopes to share more detail of his findings in future articles. * Full story DEMOCRATIZING SCIENCE: MAKING NEUROSCIENCE EXPERIMENTS EASIER TO SHARE, REPRODUCE Researchers at the University of Washington have developed a set of tools to make one critical area of big data research— that of our central nervous system—easier to share. In a paper published online in Nature Communications, the UW team describes an open-access browser they developed to display, analyze, and share neurological data collected through a type of magnetic resonance imaging (MRI) study known as diffusion-weighted MRI. * Full story WE'LL PAY MORE FOR UNHEALTHY FOODS WE CRAVE, NEUROSCIENCE RESEARCH FINDS A study published in Proceedings of the National Academy of Sciences (PNAS) found that people will pay more money for foods they crave, regardless of the food's healthiness. The authors argue this can thwart attempts by people to eat healthier, and that these cravings can occur regardless of hunger level. * Full story FRESH FINDINGS FUEL CONTROVERSY OVER WHETHER AGING BRAINS CAN REGENERATE Two recent studies have found opposite results as to whether adult brains continue to produce neurons after a certain age. The studies used different imaging protocols, which might have been a factor in the mixed results. Another factor might be that because all of the brains were analyzed post-mortem, it was difficult to make a firm assessment regarding neurogenesis. * Full story A HEAVY WORKING MEMORY LOAD COULD SINK BRAINWAVE "SYNC" A study published in the journal Cerebral Cortex determined that once a brain reaches maximum working memory capacity, certain regions of the brain might not synchronize and communicate effectively, essentially resulting in memory overload. The study used a "spot the difference" game with animals, while measuring their brain waves. * Full story NANOPARTICLES MIGHT CAUSE DNA DAMAGE TO BRAIN CELLS ACROSS A CELLULAR BARRIER New research shows that when cellular barriers are exposed to metal nanoparticles, cellular messengers are released that might cause damage to the deoxyribonucleic acid (DNA) of developing brain cells. The discovery could have implications for the development of potential drug targets in the treatment of neurodegenerative conditions, including Alzheimer's disease and Parkinson's disease. The research was published online in Nature Nanotechnology. * Full story LINK BET WEEN T WO ALZHEIMER'S PROTEINS EXPLAINED Research from the Washington University School of Medicine in St. Louis found that older patients with more amyloid in their brains also produce higher levels of tau, which could help lead to "more specific therapies targeting the (Alzheimer's) disease process," according to one of the authors. The researchers used stable isotope labeling kinetics (SILK) to track proteins. * Full story SYRACUSE UNIVERSIT Y RESEARCHERS ARE CLOSE TO UNDERSTANDING DISEASE MECHANISMS OF ALS Carlos A. Castaneda and Thuy Dao from Syracuse University have been working with ubiquitin, a tiny molecule that tags obsolete proteins in a cell. The researchers recently found that ubiquitin eliminates droplets of ubiquilin-2 (UBQLN2) in solution. Castaneda said the discovery is noteworthy because UBQLN2 is a protein-encoding gene, mutations to which cause amyotrophic lateral sclerosis (ALS) and various types of dementia, such as frontotemporal dementia (FTD). * Full story MUSIC LESSONS IMPROVE CHILDREN'S COGNITIVE SKILLS AND ACADEMIC PERFORMANCE Structured music lessons significantly enhance children's cognitive abilities— including language-based reasoning, short-term memory, planning, and inhibition—which lead to improved academic performance. Published in Frontiers in Neuroscience, the research is the first large- scale, longitudinal study to be adapted into the regular school curriculum. Visual arts NEWS & TRENDS Exploring the internet for the latest reports on research, products, and trends in neuroscience Innov Clin Neurosci. 2018;15(3–4):52–53 Click * to view the full news story.

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