Innovations In Clinical Neuroscience

HOTTOP Multiple Sclerosis MAR 2018

A peer-reviewed, evidence-based journal for clinicians in the field of neuroscience

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22 Hot Topics in Multiple Sclerosis [March 2018] Journal Watch Highlights of noteworthy, peer-reviewed, evidence-based articles on multiple sclerosis New brain lesions with no impact on physical disability can impact cognition in early multiple sclerosis: a 10-year longitudinal study. Wybrecht D, Reuter F, Pariollaud F, et al. PLoS One. 2017;12(11):e0184650. Summary. In this study, researchers evaluated the progression of cognitive deficits during the first 10 years of a multiple sclerosis (MS) diagnosis. Through the assessment of Expanded Disability Status Scale and neuropsychological battery in 26 patients over 10 years, researchers presented strong evidence that clinically silent T2 lesions impact cognition in early MS. * PMID: 29149177, PMCID: PMC5693435 A survey of dietary characteristics in a large population of people with multiple sclerosis. Fitzgerald KC, Tyry T, Salter A, et al. Mult Scler Relat Disord. 2018;22:12–18. [Epub ahead of print]. Summary. Using a survey of people in the North American Research Committee on MS (NARCOMS), researchers received responses from 6,990 patients with multiple sclerosis about their dietary habits. This cohort was compared to respondents of the National Health and Nutrition Examination Survey (NHANES). People from the NARCOMS had similar intakes of fruits, vegetables, legumes, and grains, while they consumed more red meat and less added sugar than the NHANES cohort. Low-carbohydrate and low-sugar diets were most popular. * PMID 29510324 Discriminative ability of quality of life measures in multiple sclerosis. Fiest KM, Greenfield J, Metz LM, et al. Health Qual Life Outcomes. 2017;15(1):246. Summary. Researchers evaluated the use of generic and disease-specific health related quality of life (HRQOL) scales to determine the effects of MS comorbidities. They concluded that disease-specific measures function better in assessing groups with or without MS comorbidities, and the Health Utilities Index-Mark III is best for discriminating between persons with differing severities of disability. * PMID: 29268750, PMCID: PMC5740906 Vitamin K2 in multiple sclerosis patients. Lasemi R, Kundi M, Moghadam NB, et al. Wien Klin Wochenschr. 2018 Mar 2. [Epub ahead of print]. Summary. Researchers studied the effects of vitamin K2 serum levels in patients with MS to determine how these levels related to disease characteristics and treatment. They found that patients with MS had vastly different vitamin K2 blood levels than controls, which they attributed to depletion, lower production in the gut, diminished absorption or, less likely, reduced intake of precursor vitamin K1. * PMID 29500722 Complementary and alternative medicine usage by multiple sclerosis patients: results from a prospective clinical study. Kim S, Chang L, Weinstock-Guttman B, et al. J Altern Complement Med. 2018 Mar 2. [Epub ahead of print]. Summary. In this study, researchers investigated the demographic characteristics of patients with MS who reported using complementary and alternative medicine (CAM). They concluded that women with a higher education level who were not currently on disease-modifying therapies were most associated with CAM usage. * PMID 29498537 Subjective cognitive fatigue and autonomic abnormalities in multiple sclerosis patients. Sander C, Hildebrandt H, Schlake HP, et al. Front Neurol. 2017;8:475. Summary. Using self-reported questionnaires, researchers investigated the relationship between cognitive fatigue and autonomic symptoms in MS patients and concluded that cognitive fatigue and autonomic dysfunction share a proportion of variance. * PMID: 28955298, PMCID: PMC5601401 MS Click * at the end of each summary to access the full abstract/article online.

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