Innovations In Clinical Neuroscience

HOTTOP Multiple Sclerosis MAR 2018

A peer-reviewed, evidence-based journal for clinicians in the field of neuroscience

Issue link:

Contents of this Issue


Page 17 of 23

R E V I E W 18 Hot Topics in Multiple Sclerosis [March 2018] more relevant impact on brain atrophy measures compared to late treatment, 3) second-line therapies generally have a more significant and long-lasting impact on MRI metrics of either brain or GM atrophy. Figure 1 reports the brain volume changes observed with some currently used DMDs and clearly shows that DMDs lessen the progression of brain atrophy observed in patients with MS to values similar to those observed in normal individuals. Of course, a direct comparison between drugs is hampered by substantial differences among the experimental design of the trials (including patient selection, clinical, and MRI parameters). AUTHOR CONTRIBUTIONS All authors have contributed to manuscript preparation. All authors read and approved the final manuscript. COPYRIGHT Copyright © The Author(s). 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. REFERENCES 1. Kalkers NF, Ameziane N, Bot JC, et al. Longitudinal brain volume measurement in multiple sclerosis: rate of brain atrophy is independent of the disease subtype. Arch Neurol. 2001;59:1572–6. 2. Giorgio A, Battaglini M, Smith SM, De Stefano N. Brain atrophy assessment in multiple sclerosis: importance and limitations. Neuroimaging Clin N Am. 2008;18:675–86. 3. Vågberg M, Lindqvist T, Ambarki K. Automated determination of brain parenchymal fraction in multiple sclerosis. AJNR Am J Neuroradiol. 2013;34(3):498–504. 4. Vollmer T, Signorovitch J, Huynh L, et al. The natural history of brain volume loss among patients with multiple sclerosis: a systematic literature review and meta-analysis. J Neurol Sci. 2015;357(1–2):8–18. 5. Chard DT, Griffin CM, Parker GJ, et al. Brain atrophy in clinically early relapsing-remitting multiple sclerosis. Brain. 2001;125:327–37. 6. Chard DT, Griffin CM, Rashid W, et al. Progressive gray matter atrophy in clinically early relapsing-remitting multiple sclerosis. Mult Scler. 2004;10:387–91. 7. Sailer M, Fischl B, Salat D, et al. Focal thinning of the cerebral cortex in multiple sclerosis. Brain. 2003;126:1734–44. 8. Tiberio M, Chard DT, Altmann DR, et al. Gray and white matter volume changes in early RRMS: a 2-year longitudinal study. Neurology. 2005;64:1001–7. 9. Audoin B, Davies GR, Finisku L, et al. Localization of gray matter atrophy in early RRMS: a longitudinal study. J Neurol. 2006;253:1495–501. 10. Calabrese M, Atzori M, Bernardi V, et al. Cortical atrophy is relevant in multiple sclerosis at clinical onset. J Neurol. 2007;254:1212–20. 11. Calabrese M, Rinaldi F, Mattisi I, et al. Widespread cortical thinning characterizes patients with MS with mild cognitive impairment. Neurology. 2010;74:321–8. 12. Ramasamy DP, Benedict RH, Cox JL, et al. Extent of cerebellum, subcortical and cortical atrophy in patients with MS: a case-control study. J Neurol Sci. 2009;282:47– 54. 13. Henry RG, Shieh M, Okuda DT, et al. Regional gray matter atrophy in clinically isolated syndromes at presentation. J Neurol Neurosurg Psychiatry. 2008;79:1236–44. 14. De Stefano N, Stromillo ML, Giorgio A, et al. Establishing pathological cut-offs of brain atrophy rates in multiple sclerosis. J Neurol Neurosurg Psychiatry. 2016;87: 93–9. 15. Calabrese M, Rinaldi F, Mattisi I, et al. The predictive value of gray matter atrophy in clinically isolated syndromes. Neurology. 2011;77:257–63. 16. Battaglini M, Giorgio A, Stromillo ML, et al. Voxel-wise assessment of progression of regional brain atrophy in relapsing remitting multiple sclerosis. J Neurol Sci. 2009;282:55–60. 17. Sepulcre J, Sastre-Garriga J, Cercignani M, Iet al. Regional gray matter atrophy in early primary progressive multiple sclerosis: a voxel-based morphometry study. Arch Neurol. 2006;63:1175–80. 18. Ceccarelli A, Rocca MA, Pagani E, et al. A voxel-based morphometry study of gray matter loss in MS patients with different clinical phenotypes. NeuroImage. 2008;42:315–22. 19. Sicotte NL, Kern KC, Giesser BS, et al. Regional hippocampal atrophy in multiple sclerosis. Brain. 2008;131:1134–41. 20. Tao G, Datta S, He R, et al. Deep gray matter atrophy in multiple sclerosis: a tensor based morphometry. J Neurol Sci. 2009;282:39–46. 21. Anderson VM, Fisniku LK, Khaleeli Z, et al. Hippocampal atrophy in relapsing-remitting and primary progressive MS: a comparative study. Mult Scler. 2010;16:1083–90. 22. Audoin B, Zaaraoui W, Reuter F, et al. Atrophy mainly affects the limbic system and the deep gray matter at the first stage of multiple sclerosis. J Neurol Neurosurg Psychiatry. 2010;81:690–5. 23. Audoin B, Zaaraoui W, Reuter F, et al. Subcortical atrophy and cognition: sex effects in multiple sclerosis. Neurology. 2012;79:1754–61. 24. Cifelli A, Arridge M, Jezzard P, et al. Thalamic neurodegeneration in multiple sclerosis. Ann Neurol. 2002;52:650–3. 25. Carone DA, Benedict RH, Dwyer MG, et al. Semi-automatic brain region extraction (SABRE) reveals superior cortical and deep gray matter atrophy in MS. NeuroImage. 2006;29:505–14. 26. Houtchens MK, Benedict RH, Killiany R, et al. Thalamic atrophy and cognition in multiple sclerosis.

Articles in this issue

Links on this page

Archives of this issue

view archives of Innovations In Clinical Neuroscience - HOTTOP Multiple Sclerosis MAR 2018