Innovations In Clinical Neuroscience

HOTTOP Multiple Sclerosis DEC 2017

A peer-reviewed, evidence-based journal for clinicians in the field of neuroscience

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25 Hot Topics in Multiple Sclerosis [December 2017] News & Trends Exploring multiple sclerosis in the media GENENTECH AND UNITED STATES NEUROLOGISTS ARE INCREASINGLY FOCUSED ON OCREVUS POSITIONING IN RELAPSING FORMS OF MULTIPLE SCLEROSIS Seven months post-launch, the clear majority of United States neurologists (n=103) have initiated at least one patient on Genentech's Ocrevus, with the brand share being boosted by uptake in patients with both relapsing remitting multiple sclerosis (RRMS) and primary progressive multiple sclerosis (PPMS). Reflecting the great unmet need for PPMS treatments and Ocrevus' first-in-class PPMS label, Ocrevus prescribers and nonprescribers do not differ in their sizeable and stable PPMS candidate pool estimates for the brand. Neurologists now estimate that significantly more patients with RRMS—up 50 percent compared to three months—are appropriate candidates for Ocrevus. * More information PRO-INFLAMMATORY BAC TERIA FOUND IN MULTIPLE SCLEROSIS PATIENTS ARE WHY RESEARCHERS VIEW THE MICROBIOME AS A POTENTIAL TARGET At the Proceedings of the National Academy of Sciences, researchers found that patients with multiple sclerosis (MS) had a higher concentration of pro-inflammatory bacteria and lower concentrations of anti-inflammatory bacteria. The findings suggest that continuing to study the microbiome in patients with MS could help continue the search for better, more effective treatments. * More information CALIFORNIA RESIDENT GETS LIFE-CHANGING TREATMENT FOR MULTIPLE SCLEROSIS IN RUSSIA A man from California underwent a hematopoietic stem cell transplantation in Russia to treat his multiple sclerosis. The process required stem cells to be extracted and frozen, and then after four days of chemotherapy to kill his current immune system, the stem cells were put back into his body to allow new blood and bone marrow to grow and build a new immune system. His MS is now in remission. * More information NEUROGRAPHIC MRI REVEALS PERIPHERAL NERVE LESIONS IN PATIENTS WITH MULTIPLE SCLEROSIS A study in Annals of Neurology found higher levels of peripheral nerve lesions in patients with multiple sclerosis compared to the control group. The researchers noted that while they were unsure whether this was because of an inflammatory process or spinal cord lesions, it means demyelination could be occurring in the peripheral nerve system. * More information THIS POPULAR EXERCISE COULD HELP EASE MULTIPLE SCLEROSIS SYMPTOMS Aquatic exercises could help ease the symptoms of multiple sclerosis for a variety of reasons, such as viscosity of the water, hydrostatic pressure, and temperature control, according to the National Multiple Sclerosis Society. * More information MAYO CLINIC DEVELOPS NEURO TEST THAT DISTINGUISHES DEMYELINATING DISEASES FROM MULTIPLE SCLEROSIS Mayo Clinic has launched a first-in-the- United States clinical test that will help patients who recently have been diagnosed with an inflammatory demyelinating disease (IDD) but might be unsure of the exact disorder. Neurologic-related diseases commonly affect the brain, optic nerves, and the spinal cord, and this new test can distinguish other IDDs, such as neuromyelitis optica, acute disseminated encephalomyelitis, optic neuritis, and transverse myelitis from multiple sclerosis. * More information RESEARCH PINPOINTS POWERFUL BIOMARKER OF MULTIPLE SCLEROSIS Researchers found a biomarker of multiple sclerosis (MS) that could be used in a blood test to potentially help diagnose the disease. They found nine unique Click * at the end of each summary to access the full news item online.

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