Innovations In Clinical Neuroscience

Summit 2017

A peer-reviewed, evidence-based journal for clinicians in the field of neuroscience

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ICNS Innovations in Clinical Neuroscience • November–December 2017 • Volume 14 • Number 11–12 • Supplement S4 CNS Summit 2017—Abstracts of Poster Presentations TABLE OF CONTENTS VOL. 14, NO. 11–12 • NOVEMBER–DECEMBER 2017 • SUPPLEMENT November 16–19, 2017 • Boca Raton, Florida Biomarkers and Imaging........................ S5 • KINARM Labs: Better behavior biomarkers using robot- based assessment • Multiplexed mass spectrometry assay identifies neurodegeneration biomarkers in CSF Digital Tools and Technology...................S5 • Digital technologies in Alzheimer's Disease Trials • The Early Psychosis Screener (EPS): a validated accurate web-based self-report screener for prodromal and early psychosis • Innovation implemented: changing Otsuka's business model through the ePlatform • Technology-enhanced learning for researchers to support of capacity building in clinical development Investigative Drug Compounds/Therapies....S7 • Efficacy of vortioxetine in working patients with generalized anxiety disorder • An intranasal aerosol for social anxiety disorder • Lamotrigine for ketamine dependence: a randomized, double-blind, placebo-controlled trial • PH94B nasal spray a PRN treatment for social anxiety disorder: a Phase 3 pilot trial • A retrospective case-matched study of the efficacy of the MedicaSafe BupeCare Device • Scientific rationale and clinical development of AXS-05 for neuropsychiatric disorders • Tolperisone shows no evidence of sedation compared to cyclobenzaprine and placebo in a driving simulation study Mobile Technology............................... S10 • High frequency assessment of mood and cognition in major depressive disorder using the Apple Watch • Patient engagement text messaging reduces drug interruption and patient dropout in Phase 3 bipolar depression clinical trial • Project STARR911 • Validity and retest-reliability of sleep measurements using a simple, self-applicable device Patient Assessment and Adherence...........S11 • Criteria satisfied on diagnostic instrument often not confirmed on severity ratings • Data quality concerns associated with PANSS negative items—an exploratory analysis • Effect of predominance of negative symptoms at baseline on change in the PANSS total in acute schizophrenia trials—an exploratory analysis • Real-world patient experience with treatment-emergent sexual dysfunction in depression • The SAGE-SR: Item development and initial validation of a DSM-5 and SCID-based self-report diagnostic assessment • Subjects' knowledge of symptoms that can occur during seizures • Training, above all other motivators, is preferred by subjects with CNS disorders for motivating them to complete daily questionnaires Patient Recruitment..............................S14 • How to scale up recruitment in Alzheimer's disease clinical trials from 3 to 100 screens a month • Patient recruitment campaign strategies and effectiveness in a clinical trial of patients with opioid use disorder • Patient selection for CNS clinical trials: findings from an eligibility review database with a focus on Alzheimer's Disease trials • You show me your (I/E) and I'll show you my (diagnosis): professional subjects changing indications Placebo Response............................... S15 • Mitigating placebo response in CNS clinical trials: a site- based pilot program • The power of an educational placebo response video: strengthening subject placebo response awareness across demographic variables and diagnoses Rater Assessment and Training................ S16 • Distribution of performance and incorrect ratings in qualification video scoring • Identification of Children's Depression Rating Scale— Revised (CDRS-R) items of particular challenge to raters in child and adolescent depression clinical trials outside of the United States. Trial Protocol......................................S17 • A retrospective analysis of the effects of protocol design on completion rates in outpatient clinical trials in subjects with schizophrenia or schizoaffective disorder • Towards more efficient methods for COA instrument selection in clinical trials ICNS

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