Innovations In Clinical Neuroscience

HOTTOP Multiple Sclerosis DEC 2017

A peer-reviewed, evidence-based journal for clinicians in the field of neuroscience

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Hot Topics in Multiple Sclerosis [December 2017] 24 Journal Watch Highlights of noteworthy, peer-reviewed, evidence-based articles on multiple sclerosis A supervised framework with intensity subtraction and deformation field features for the detection of new T2-w lesions in multiple sclerosis. Salem M, Cabezas M, Valverde S, et al. Neuroimage Clin. 2017 Nov 20;17:607- 615. doi: 10.1016/j.nicl.2017.11.015. eCollection 2018. Summary. New T2-w lesions on brain magnetic imaging resonance (MRI) scans are a biomarker of multiple sclerosis (MS), and researchers laid out a procedure to detect these lesions. Researchers determined that using deformation fields operators to train a supervised learning model was successful, and the overall process reduces the number of false- positives. * PMID 29234597, PMCID: PMC5716954 Functional components of cognitive impairment in multiple sclerosis: a cross- sectional investigation. Matias-Guiu JA, Cortes-Martinez A, Valles- Salgardo M, et al. Front Neurol. 2017 Nov 28;8:643. doi: 10.3389/fneur.2017.00643. eCollection 2017. Summary. There is a clear relationship between cognitive impairment (CI) and multiple sclerosis (MS), especially its effect on information processing speed. CI was found in 41.5 percent of the study's 311 patients, and it was most common in patients with secondary progressive MS (SPMS) and primary progressive MS (PPMS). Scores from the Expanded Disability Status Scale (EDSS), as well as education, were predictors of CI. * PMID 29234305, PMCID: PMC5712315 Relapsing-remitting multiple sclerosis at remission stage treated with acupuncture: a randomized controlled trial. Wang C, Chen Z, Wang L, et al. Zhongguo Zhen Jiu. 2017 Jun 12;37(6):576-580. doi: 10.13703/j.0255-2930.2017.06.002. Summary. Acupuncture and shallow needling therapy was tested on patients with relapsing remitting multiple sclerosis (RRMS) and compared to a control group to determine their effect. Researchers concluded that acupuncture was therapeutic in patients with RRMS at the remission stage. * PMID 29231495 Structural abnormalities and altered regional brain activity in multiple sclerosis with simple spinal cord involvement. Yin P, Liu Y, Xiong H, et al. Br J Radiol. 2017 Dec 11:20150777. doi: 10.1259/ bjr.20150777. [Epub ahead of print] Summary. Structural and functional abnormalities were tested in patients with multiple sclerosis with simple spinal cord involvement (MS-SSCI) via resting-state functional magnetic resonance imaging (RS-fMRI), the first study to do so. They were able to detect abnormalities in patients with MS-SSCI and noted that multimodal imaging was an important factor in this determination. * PMID 29227148 A multicenter randomized controlled trial of two group education programs for fatigue in multiple sclerosis: short- and medium-term benefits. Hugos CL, Chen Z, Chen Y, et al. Mult Scler. 2017 Dec 1:1352458517745723. doi: 10.1177/1352458517745723. [Epub ahead of print] Summary. This study compared a pair of programs designed to improve fatigue in patients with multiple sclerosis (MS)—Fatigue: Take Control (FTC) and MS: Take Control (MSTC). Using a primary outcome of Modified Fatigue Impact Scale (MFIS) scores, researchers found that FTC improved self-reported fatigue measurements for up to six months, but that its results were not significantly different than the MSTC. * PMID 29226778 Click * at the end of each summary to access the full abstract/article online.

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