Innovations In Clinical Neuroscience

Hot Topics in Pain Management October 2017

A peer-reviewed, evidence-based journal for clinicians in the field of neuroscience

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11 Hot Topics in Pain Management [October 2017] American Pain Society 36th Annual Scientific Summit May 17–20, 2017 Pittsburgh, PA Highlights of selected presentations from the 2017 conference Meeting Highlights ABUSE-DETERRENT OPIOIDS Gill et al presented the results of their study, "Bioequivalence of abuse-deterrent, immediate-release (ADIR) oxycodone compared with IR oxycodone without abuse-deterrent properties" (Poster #239). The study demonstrated bioequivalence between oxycodone-ADIR-A 15mg and IR oxycodone 15mg. * More information Rauck et al presented the protocol of their ongoing study, "Novel design to evaluate the efficacy and safety of an abuse-deterrent, extended-release oxycodone product candidate in patients with moderate to severe chronic low back pain" (poster # 237). According to the presenters, this study will evaluate a new oxycodone abuse-deterrent, extended-release, injection-molded tablet (oxycodone-ADER-IMT) product candidate developed using proprietary Guardian™ Technology. The researchers reported that they are hoping the study demonstrates that oxycodone-ADER-IMT's extended release will allow for a longer titration/maintenance period, which is used to establish stable doses during clinical trials. Dosage data collected during the maintenance phase of clinical trials are used to determine the durability of the effect of the study drug. * More information Trudeau et al presented their study, "Natural history of prescription opioid misuse/abuse: a qualitative investigation" (poster #228), in which investigators explored the natural history of opioid misuse and abuse, looking specifically at changes in route of administration (ROA) over time. The investigators reported that there might not be a "typical" pattern of ROA progression for opioid misuse and abuse. * More information Vaugn et al presented the results of their study, "The relationship between the pharmacokinetics of morphine abuse-deterrent, extended-release, injection-molded tablets and pharmacodynamic outcomes in oral and intranasal human abuse potential studies" (poster #238). Here the investigators compared the pharmacokinetics/ pharmacodynamics (PK/PD) relationships of morphine AD extended-release (ER) injection- molded tablets (morphine-ADER- IMT) to other treatments in two single-center, double-blind crossover human abuse potential studies. Participants were volunteers who were nondependent, recreational opioid users. * More information White et al presented the results of their study, "A harm reduction model to quantify potential misuse/abuse reduction and misuse/abuse-related events avoided with extended- release abuse deterrent opioids" (poster #236), which investigated the extent of the potential to reduce opioid misuse/abuse-related events by simulating, over 5 years, the replacement of all non-AD morphine ER formulations with morphine- ADER-IMT. * More information PAIN MANAGEMENT TECHNOLOGY At APS 2017, Penn et al presented the results of their study, "Attitudes toward a virtual reality physical activity intervention among veterans with chronic low back pain." In this Sharon Keller Grant winning study, the authors collected feedback from military veterans with chronic lower back pain (CLBP) regarding an interactive virtual reality (VR) gaming intervention used to address maladaptive pain beliefs and promote physical activity. The investigators reported that, overall, their quantitative and qualitative findings demonstrated high stakeholder interest in the VR gaming paradigm. They also discussed future directions for military-specific development. Martinez et al presented their study, "Automatic pain intensity Click * at the end of each summary to access more information online.

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