Innovations In Clinical Neuroscience

MAY-JUN 2017

A peer-reviewed, evidence-based journal for clinicians in the field of neuroscience

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VOL. 14, NO. 5–6 • MAY–JUNE 2017 • INNOVATIONSCNS.COM EDITORIAL MESSAGE and Issue Highlights [ V O L U M E 1 4 , N U M B E R 3 – 4 , M A Y – J U N E 2 0 1 7 ] Innovations in CLINICAL NEUROSCIENCE 8 Follow us. Dear Colleagues: Welcome to the May-June 2017 issue of Innovations in Clinical Neuroscience. We start the issue with the review article, "The Role and Treatment Implications of Peripheral and Central Processing of Pain, Pruritus, and Nausea in Heightened Somatic Awareness: A Review," by Spiegel et al. Here, the authors describe and discuss human studies that explore acute neural transmission processes of pain, pruritus, and nausea, including how cortical and subcortical networks are activated by these symptoms. Based on the discussed research, the author then describe potential treatment options for patients who exhibit chronic symptoms of pain, pruritic, or nausea. Next, in their article, "Single Nucleotide Polymorphisms and the Central Nervous System: Potential Biomarkers in Identifying Suicide Risk," Yarlagadda, Rosenblatt, and Clayton discuss possible biological mechanisms of suicidality, including single nucleotide polymorphisms (SNPs) and their association with suicidal behaviors Following this, in the article titled, "When the Opioid Medications Go Missing: Confidentiality and Safety in Adolescents," Majeed presents a case in which an adolescent, while in treatment for depression and behavioral problems in school, admitted to stealing and using opioid pain medication belonging to her mother, but instructed the treatment team not to reveal her substance use to her family. The author discusses the professional and ethical dilemma this nondisclosure caused the treatment team, who had to not only consider the patient's safety, but also her rights to confidentiality as a minor. Next, in his commentary "It's Time for Combination Therapies in Multiple Sclerosis," Avasarala discusses the blood brain barrier as the primary limitation to the effectiveness of multiple sclerosis (MS) therapies. The author also describes the pathophysiological role of B-cells in MS disease progression and treatment and discusses potential drug development strategies for MS that combine blood brain barrier crossing molecules with peripherally acting B-cell depleting monoclonal antibodies. We close the issue with the latest installment of Risk Management by Vanderpool title, "What Can I Do About a Negative Online Review?" Here the author describes the pros and cons of potential actions a clinician can take when faced with a negative online review. We hope you enjoy the issue. As always, we welcome your feedback and submissions. Sincerely Amir Kalali, MD Editor, Innovations in Clinical Neuroscience JOURNAL STAFF E ditor Amir H. Kalali, MD P rofessor of Psychiatry, University of California San Diego, California Executive Editor E lizabeth A. Klumpp Matrix Medical Communications West Chester, Pennsylvania M anaging Editor Angela M. Saba M atrix Medical Communications West Chester, Pennsylvania Assistant Editor J ulia E. Eckert Matrix Medical Communications W est Chester, Pennsylvania Assistant Editor Frank Hosking III M atrix Medical Communications West Chester, Pennsylvania Assistant Editor A ustin K. Vitelli Matrix Medical Communications W est Chester, Pennsylvania BUSINESS STAFF Matrix Medical Communications West Chester, Pennsylvania P resident/Group Publisher Robert L. Dougherty Vice President, Publisher Joseph J. Morris Vice President, Editorial Director Elizabeth A. Klumpp Vice President, Business Development and Finance C hristine C. Franey Associate Director of Business Development Christopher Moccia Partner Patrick D. Scullin Editorial Queries Elizabeth A. Klumpp Phone: (484) 266-0702 E-mail: Advertising Queries Robert L. Dougherty Phone: (484) 266-0702 E-mail: Indexing PubMed Central, PsycINFO, CINAHL ® Plus with Full Text, Scopus, and Embase Innovations in Clinical Neuroscience, ISSN 2158-8333 (Print) and ISSN 2158-8341(Online), is published electronically 6 times yearly by Matrix Medical Communications via To receive an e-mail when a new issue is available and/or to access full content online, please visit and complete the online registration form. Registration and access are free to qualified professionals. Innovations in Clinical Neuroscience is not intended for patients or consumers. Copyright © 2017 Matrix Medical Communications. All rights reserved. Opinions expressed by authors, contributors, and advertisers are their own and not necessarily those of Matrix Medical Communications, the editorial staff, or any member of the editorial advisory board. Matrix Medical Communications is not responsible for accuracy of dosages given in the articles printed herein. The appearance of advertisements in this journal is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality, or safety. Matrix Medical Communications disclaims responsibility for any injury to persons or property resulting from any ideas or products referred to in the articles or advertisements.

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