Innovations In Clinical Neuroscience

CNS Summit 2016

A peer-reviewed, evidence-based journal for clinicians in the field of neuroscience

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[ V O L U M E 1 4 , N U M B E R 1 – 2 , J A N U A R Y – F E B R U A R Y 2 0 1 7 , S U P P L E M E N T ] Innovations in CLINICAL NEUROSCIENCE S13 New York, New York, and consultants to Takeda. Xinxin Dong, Elizabeth Hanson, Thomas A. Macek, Atul Mahableshwarkar, a nd Maggie McCue are employees of Takeda Development Center Americas, Inc., Deerfield, Illinois. Anne Rubin is a former employee of Takeda. O ptimizing the mobile clinical trial: data collection through a web-based platform in telemedicine protocol Presenters: Shaw M 1 , Song G 2 , Charvet L 1 , Beringer J 3 , Waibel U 3 Affiliations: 1 NYU School of Medicine, New York, New York; 2 Stony Brook Medicine, Stony Brook, New York; 3 Berisoft Corp., Redwood City, California Objective: A web-based platform was employed to administer cognitive testing and self-reported mood in a clinical trial where the intervention was administered remotely to participants at home through telerehabilitation. Design: Using a remotely supervised telemedicine protocol, our study tested the benefit of transcranial direct current stimulation (tDCS) for participants with multiple sclerosis (MS). Participants completed daily assessments along with their treatments through a study-provided laptop. To avoid paperwork and to access data in real-time, we utilized the ERTSLab online platform, administrable from any computer with an internet connection. Cognitive functioning was measured by the Attention Networks Test-Interaction (ANT-I) and self-reported mood was measured using the Positive and Negative Affect Schedule (PANAS) taken from the Cognition Library of ERTSLab. Results: For the ANT-I, excellent form reliability was found between ERTSLab and the PC-installed ePrime version. Form reliability was excellent (r=0.90). Using the ERTSLab version, in our MS sample we found significant improvement in alerting scores for the treatment (n=6) versus control (n=4) conditions (p=0.031). For the PANAS, the self- reported mood measure, online versus standard forms were similarly validated (r=0.90). For the study, 13 participants completed a daily PANAS assessment along with their treatment sessions, and we found a trend toward statistically significant improvement in positive (p=0.001) and negative (p=0.70) affects for those in the treatment versus control condition. Conclusion: Online platforms such as E RTSLab provide a mobile platform to administer cognitive assessment and self- reported symptom inventories in study designs where participants are assessed in remote locations including the use of t elerehabilitation. Disclosures/funding: None reported. PATIENT ASSESSMENT AND ADHERENCE Are there reporting differences at screening on the Montgomery-Äsberg Depression Rating Scale (MADRS) between older and younger adults when using remote assessments? Presenters: Yavorsky C, Seglund P, Engelhardt N, McNamara C Affiliations: All authors employees of Cronos CCS, Lambertville, New Jersey Objective: Our objective was to assess whether differences exist between two age groups of patients (older adults and younger adults) at screening by comparing mean MADRS scores and individual item differences. Design: An independent samples t-test was performed to compare means at screening for the two age groups (younger adults and older adults). Analysis was conducted using SPSS 21.0 for Windows. Specific item analysis was also conducted to determine if there were effects related to symptom domain. Results: There was a significant difference (t[55]=51.45, p<0.0001) between the two groups, with the younger patient cohort having significantly higher scores at screening than the older patient cohort. Conclusion: There were significant differences between older and younger patient cohorts at screening, with older adults reporting less severity than younger adults. There is a paucity of research around phone versus face-to-face interviewing in older adults in terms of rapport and acceptability. These findings suggests there may be real differences that merit further study to determine if the effect is related to characteristics of the geriatric depression population or the methods and expectations about telephone interviewing in this patient group. Disclosures/funding: All authors are employees of Cronos CCS, Lambertville, New Jersey, and report no conflicts of i nterest. Cultural adaptation of the Virtual Reality Functional Capacity Assessment Tool (VRFCAT) for use in the UK and Canada P resenters: Atkins A 1 , Saxby B 1 , 2 K elly S 1 , Hamby M 1 , Roux P 1 , Gonzalez M 1 , Madden J 1 , Stankovic M 1 , Keefe R 1 , 3 Affiliations: 1 NeuroCog Trials, Durham, North Carolina; 2 Institute for Ageing, Newcastle University, Newcastle, United Kingdom; 2 Duke University Medical Center, Durham, North Carolina Objective: The Virtual Reality Functional Capacity Assessment Tool (VRFCAT) uses a computer-simulated environment to assess a subject's ability to complete instrumental activities associated with a shopping trip. With six alternate forms to prevent practice effects, the VRFCAT has demonstrated high test-retest reliability and has shown sensitivity to functional impairment in schizophrenia. Originally developed in English for the United States, we describe cultural adaptation of the VRFCAT for use in the United Kingdom and Canada. Design: Our method for cultural adaptation followed recommendations of the International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Cultural adaptation was completed independently by two cultural experts in each region using concept sheets, screenshots, and additional task materials. Discrepancies were reconciled through discussion and ultimate consensus among reviewers and content experts. Results: Culturally adapted test versions were created based on thorough review of feedback received from in-country reviewers. Culturally specific graphic and audio content were created, including design of virtual environments, objects and icons, and professional recording of voiceovers. Other culturally specific changes included revisions of wording (e.g., changing "apartment" to "flat" for the United Kingdom, currency, and prices. Customization of food items and recipes were required to account for cultural differences in item frequency and familiarity. More extensive adaptation was

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