A peer-reviewed, evidence-based journal for clinicians in the field of neuroscience
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L E T T E R S T O T H E E D I T O R [ V O L U M E 1 4 , N U M B E R 1 – 2 , J A N U A R Y – F E B R U A R Y 2 0 1 7 ] Innovations in CLINICAL NEUROSCIENCE 13 n ervous system function is well known, but its effects on glucose homeostasis and pancreatic beta-cell function are not well understood. Further studies on the role D 2 receptors play in glucose regulation are needed. Antipsychotics may cause metabolic dysregulation, which can result not only in hyperglycemia but also in hypoglycemia, as was seen in our patient. References. 1. Newcomer JW, Haupt DW, Fucetola R et al. Abnormalities in glucose regulation during antipsychotic treatment of schizophrenia. Arch Gen Psychiatry. 2002;59:337–345. 2. Nagamine T. Hypoglycemia associated with insulin hypersecretion following the addition of olanzapine to conventional antipsychotics. Neuropsychiatr Dis Treat. 2006;2:583–585. 3. van Keulen K, van der Linden PD, Souverein PC et al. Risk of Hospitalization for hypoglycemia in older patients with diabetes using antipsychotic drugs. Am J Geriatr Psychiatry. 2015;23(11):1144–1153. 4. van Winkel R, De Hert M. Drug hypoglycaemia. Reactive hypoglycaemia in severe mental illness. BMJ. 2009;338:b2536. 5. Nagamine T. Severe hypoglycemia associated with risperidone. Psychiatry Clin Neurosci. 2016. doi: 10.1111/pcn.12416. [Epub ahead of print] 6. Cryer PE, Axelrod L, Grossman AB et al. Diagnostic accuracy of an "amended" insulin-glucose ratio for the biochemical diagnosis of insulinomas. Ann Intern Med. 2013;158:500–501. 7. Leonard CE, Bilker WB, Brensinger CM et al. Severe hypoglycemia in users of sulfonylurea antidiabetic agents and antihyperlipidemics. Clin Pharmacol Ther. 2016;99:538–547. 8. Satoh H, Terai T, Nakanishi H et al. Effect of tiapride on the activity of neuroleptics and other kinds of drugs in mice and rats. Nihon Yakurigaku Zasshi. 1988;91:71–80. 9. Vezzosi D, Bennet A, Fauvel J et al. Insulin levels measured with an insulin-specific assay in patients with fasting hypoglycaemia related to endogenous hyperinsulinism. Eur J Endocrinol. 2003;149:413–419. 10. Shankar E, Santhosh KT, Paulose CS. Dopaminergic regulation of glucose- induced insulin secretion through dopamine D 2 receptors in the pancreatic islets in vitro. IUBMB Life. 2006;58(3):157–163. 11. Garcia-Tornadú I, Perez-Millan MI, Recouvreux V et al. New insights into the endocrine and metabolic roles of dopamine D 2 receptors gained from the Drd2 mouse. Neuroendocrinology. 2010;92(4):207–214. With regard, Takahiko Nagamine, MD, PhD Sunlight Brain Research Center, Hofu City, Yamaguchi, Japan Address for correspondence. Takahiko Nagamine, MD, PhD, Sunlight Brain Research Center, 4-13-18 Jiyugaoka, Hofu City, Yamaguchi, 747- 0066, Japan; e-mail: email@example.com Funding/financial disclosures. No funding was received for the preparation of this article. The author has no conflicts of interest relevant to the content of this letter.