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Hot Topics in Pain Management [August 2016] 9 ABSTRACT Background. Pain management has been considered as significant contributor to broad quality-of-life improvement for cancer patients. Modulating serum cholesterol levels affects analgesia abilities of opioids, important pain killer for cancer patients, in mice system. Thus the correlation between opioids usages and cholesterol levels were investigated in human patients with lung cancer. Methods. Medical records of 282 patients were selected with following criteria, 1) signed inform consent, 2) full medical records on total serum cholesterol levels and opioid administration, 3) opioid-naïve, 4) not received/receiving cancer-related or cholesterol lowering treatment, 5) pain level at level 5–8. The patients were divided into different groups basing on their gender and cholesterol levels. Since different opioids, morphine, oxycodone, and Opioid Doses Required for Pain Management in Lung Cancer Patients with Different Cholesterol Levels: Negative Correlation Between Opioid Doses and Cholesterol Levels Lipids in Health and Disease 2016;15:47 DOI: 10.1186/s12944-016-0212-9 by ZHENHUA HUANG †,1 , LINING LIANG †,2 , LINGYU LI, †,2,3 MIAO XU, 4–6 XIANG LI, 2 HAO SUN, 2 SONGWEI HE, 2 LILONG LIN, 2 YIXIN ZHANG, 2 YANCHENG SONG, 7 MAN YANG, 8 YULING LUO, 8 HORACE H. LOH, 9 PING- YEE LAW, 9 DAYONG ZHENG, 8 and HUI ZHENG †,2 1 Department of Oncology, Nanfang Hospital, Southern Medical University; 2 CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences; 3 Anhui University; 4 Sun Yat-sen University Cancer Center; 5 State Key Laboratory of Oncology in South China; 6 Collaborative Innovation Center for Cancer Medicine; 7 The third hospital, Southern Medical University; 8 Department of Neurology, Nanfang Hospital, Southern Medical University; 9 Department of Pharmacology, University of Minnesota †Contributed equally FUNDING: This work has been supported by FUNDING: This work has been supported by the "Guangdong Natural Science Foundation (2014A030308002)", the "Guangdong Science and Technology Planning Project (2013B010404040)", the "Guangdong special support program (2014TQ01R157)" the support program (2014TQ01R157)" the "Guangzhou science and technology project (201508020250)", and the Special Foundation for National Clinical Specialties of China (to Department of Oncology, Nanfang China (to Department of Oncology, Nanfang Hospital). COMPETING INTERESTS: The authors declare that all authors have no competing interests as defined, or other interests that might be perceived to influence the results and discussion reported in this paper. discussion reported in this paper. KEY WORDS: Cholesterol level, opioid, KEY WORDS: Cholesterol level, opioid, KEY WORDS: Cholesterol level, opioid, analgesia, lung cancer patients COPYRIGHT: © Huang et al. 2016. This article COPYRIGHT: © Huang et al. 2016. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http:// creativecommons. org/ licenses/ by/ 4. 0), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http:// creativecommons. org/ publicdomain/ zero/ 1. 0/ ) applies to the data made available in this article, unless otherwise stated. in this article, unless otherwise stated. RECEIVED: 18 November 2015; ACCEPTED: RECEIVED: 18 November 2015; ACCEPTED: 24 February 2016; PUBLISHED: 8 March 2016 R E S E A R C H