Innovations In Clinical Neuroscience

Pain Management August 2016

A peer-reviewed, evidence-based journal for clinicians in the field of neuroscience

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Hot Topics in Pain Management [August 2016] 17 comparison of acute and chronic signaling to adenylyl cyclase. J Biol Chem. 2009;284:22108–22. 20. Alfaro MJ, Ormazabal MJ, Garcia- Arroba L, Martin MI. Cholesterol- fed rabbits: study of the response of the vas deferens to adrenergic and non-adrenergic stimulus and to a kappa-opioid agonist. J Pharm Pharmacol. 1996;48:433–6. 21. Hong QY, Wu GM, Qian GS, Hu CP, Zhou JY, Chen LA, et al. Prevention and management of lung cancer in China. Cancer. 2015;121 Suppl 17:3080–8. 22. Shi Y, Sun Y. Medical management of lung cancer: experience in China. Thorac Cancer. 2015;6:10–6. 23. Yang W, Xiao J, Yang Z, Ji L, Jia W, Weng J, et al. Serum lipids and lipoproteins in Chinese men and women. Circulation. 2012;125:2212–21. 24. Zheng H, Chu J, Zhang Y, Loh HH, Law PY. Modulating micro-opioid receptor phosphorylation switches agonist-dependent signaling as reflected in PKCepsilon activation and dendritic spine stability. 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Neurofilament proteins and cAMP pathway in brains of mu-, delta- or kappa-opioid receptor gene knock- out mice: effects of chronic morphine administration. Neuropharmacology. 2004;46:519– 30. 32. Dietschy JM, Turley SD. Control of cholesterol turnover in the mouse. J Biol Chem. 2002;277:3801–4. 33. Barnett-Norris J, Lynch D, Reggio PH. Lipids, lipid rafts and caveolae: their importance for GPCR signaling and their centrality to the endocannabinoid system. Life Sci. 2005;77:1625–39. 34. Bliss SP, Navratil AM, Breed M, Skinner DC, Clay CM, Roberson MS. Signaling complexes associated with the type I gonadotropin-releasing hormone (GnRH) receptor: colocalization of extracellularly regulated kinase 2 and GnRH receptor within membrane rafts. Mol Endocrinol. 2007;21:538–49. 35. Navratil AM, Bliss SP, Berghorn KA, Haughian JM, Farmerie TA, Graham JK, et al. Constitutive localization of the gonadotropin- releasing hormone (GnRH) receptor to low density membrane microdomains is necessary for GnRH signaling to ERK. J Biol Chem. 2003;278:31593–602. 36. Morris DP, Lei B, Wu YX, Michelotti GA, Schwinn DA. The alpha1a-adrenergic receptor occupies membrane rafts with its G protein effectors but internalizes via clathrin-coated pits. J Biol Chem. 2008;283:2973–85. 37. Bari M, Battista N, Fezza F, Finazzi-Agro A, Maccarrone M. Lipid rafts control signaling of type-1 cannabinoid receptors in neuronal cells. Implications for anandamide-induced apoptosis. J Biol Chem. 2005;280:12212–20. 38. Eglen RM, Reisine T. New insights into GPCR function: implications for HTS. Methods Mol Biol. 2009;552:1–13. 39. Eglen RM. Functional G protein- coupled receptor assays for primary and secondary screening. Comb Chem High Throughput Screen. 2005;8:311–8. 40. Lewington S, Whitlock G, Clarke R, Sherliker P, Emberson J, Halsey J, et al. 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