Innovations In Clinical Neuroscience

2015 Abstracts of Poster Presentations

A peer-reviewed, evidence-based journal for clinicians in the field of neuroscience

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Innovations in CLINICAL NEUROSCIENCE [ V O L U M E 1 2 , N U M B E R 1 1 – 1 2 , N O V E M B E R – D E C E M B E R 2 0 1 5 , S U P P L E M E N T C ] 8 instruments. Alexandra S. Atkins, Vicki Davis, Tina Tseng, and Adam Vaughan are employees of NeuroCog Trials. Philip Harvey receives r oyalties for the BACS and the BAC App. Relationship between the Positive and Negative Syndrome Scale (PANSS) and a self- reported level of functioning, measured by the Specific Level of Functioning Assessment Scale (SLOF) among patients with schizophrenia Presenters: 1 , 2 Opler M, 1 Lam J, 1 Tatsumi K, 1 , 3 Khan A, 1 , 4 Rothman B Affiliations: 1 ProPhase LLC; 2 New York University, School of Medicine; 3 Nathan S. Kline Institute for Psychiatric Research, Manhattan Psychiatric Center; 4 Teachers College/Columbia University Background: Salient impairment in everyday functional skills, such as basic self-care, interpersonal relationships, and occupational functioning, are present in patients with schizophrenia (Murray CJL et al., 1997; Wiersma D et al., 2000). Objectives: However, there is often a discrepancy between objective and subjective evaluations of functional impairment for patients diagnosed with psychotic disorders (Bowie et al., 2007). This study aimed to examine the relationship between clinician perceptions of psychiatric severity and patient- reported perceptions of functional impairment. Methods: Data analyzed in this study was originally collected for the Validation of Everyday Real-World Outcomes (VALERO) study. Inpatient adults with a diagnosis of schizophrenia (N=239) were evaluated with the PANSS by clinicians. Using a modified version of the SLOF, patients also reported their own perception of their level of social functioning. On the basis of PANSS anchor/behavioral descriptors, each PANSS individual item was dichotomized as showing either functional impairment (coded as "1") or no functional impairment (coded as "0"). These items were then summed to create a PANSS functional impairment score. Via correlational analyses, the only significant r elationship found between these two measures was between the PANSS total functional impairment score and the SLOF interpersonal relationships subscale score (r= -0.148, p<0.05). Conclusion: This suggests that patients with high levels of psychiatric severity are most likely to report only impairments in social functioning. In other words, patients may be less aware of deficits in other domains of functioning that exist. Further analyses will follow. Rosenberg Hassman Mood Scale: assessing understanding of impairment self-rating instructions Presenters: Rosenberg L, Marini T Affiliations: Center for Emotional Fitness Background: Problem Statement: The Rosenberg Hassman Mood Scale (RHMS) is a frequency-based depression severity scale. To meet DSM-5 criteria for a major depressive episode (MDE), the depression- related "symptoms must cause clinically significant distress or impairment in social, occupational, or other important areas of functioning." "Symptoms" refer to the nine biologically based symptoms of an MDE listed in DSM-5. The RHMS expanded the nine DSM-5 symptoms into 23 depression topics. Each topic is sub-divided into 5 to 9 synonyms resulting in 163 possible symptoms of depression. Accurately correlating the nine symptoms of an MDE to distress or impairment has historically been difficult; accurately correlating the 163 RHMS symptoms in the 23 RHMS topics to the three distress/impairment questions is likely to be difficult as well. Objective: To measure the understandability of the RHMS distress/impairment questions' instructions Methods: After completing the RHMS, 20 adult subjects with MDE were instructed to complete the RHMS impairment questions using the instructions as they now appear. 20 additional subjects used I nstruction Variation 1 and 20 used Instruction Variation 2. All subjects were then given the same five- question multiple choice quiz. Quiz responses determined the level of accuracy of the subjects' understanding of the various instructions. Results: The RHMS instructions for the three distress/impairment questions lack clarity in explaining the correlation of symptoms to distress or impairment. Variations 1 and 2 appear to demonstrate improved understanding of the correlation of symptoms to distress or impairment. Statistical analysis will be presented. Utilization of baseline patient characteristics to determine minimal clinically important differences (MCID) and clinically relevant treatment response for the UCSD Performance-Based Skills Assessment (UPSA) in 600 patients with major depressive disorder (MDD) Presenters: 1 Harvey P, 2 Jacobson W, 2 Merikle E, 2 Zhong W, 2 Nomikos G, 3 Olsen CK, 3 Christensen MC Affiliations: 1 University of Miami Miller School of Medicine; 2 Takeda Development Center Americas; 3 H. Lundbeck A/S Background: The UCSD Performance-Based Skills Assessment (UPSA) has been extensively utilized in patients with schizophrenia and bipolar disorder to measure functional capacity. Objective: This post-hoc analysis of NCT01564862 reports the psychometric properties of the UPSA in patients with MDD in an outpatient clinical trial setting. Methods: Patients with MDD (18–65yrs, MADRS ≥26) with self- reported cognitive dysfunction were enrolled in an eight-week, double- blind, placebo-controlled study. Clinical outcomes included DSST,

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