Innovations In Clinical Neuroscience

Current Trends in Epilepsy 2015

A peer-reviewed, evidence-based journal for clinicians in the field of neuroscience

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Current Trends in Epilepsy Management [December 2015] 12 are urging parents and p ediatricians not to wait for children to fail on multiple medications before being evaluated for surgery. To access the interview, visit http://www.houstonchronicle.com/n ews/houston- texas/houston/article/Doctors-urge- reconsideration-of-surgery-for- 6659175.php * WHOLE EXOME SEQUENCING EFFECTIVE FOR EPILEPSY DIAGNOSIS IN CHILDREN Research suggests that whole exome sequencing can identify the genetic cause of seizures in children under the age of 5 with onset of epilepsy, with more than 15% of the diagnoses having immediate treatment implications. For more information, visit http://www.neurologyadvisor.com/a es-2015/whole-exome-sequencing- children-epilepsy- diagnosis/article/457364/ * BIOFEEDBACK REDUCES SEIZURES IN INTRACTABLE EPILEPSY New research is showing that biofeedback, a technique using the mind to control physiologic responses, such as heart rate and respiration, can reduce seizure frequency. For more information, http://www.medscape.com/viewartic le/855754 * SEATTLE CHILDREN'S RESEARCHERS IDENTIFY DRUG THAT COULD SUPPRESS INTRACTABLE EPILEPSY Scientists at Seattle Children's Research Institute have found a way to rapidly suppress epilepsy in mouse models by manipulating a known genetic pathway using a cancer drug currently in human clinical trials for the treatment of brain and breast cancer. For more information, http://www.newswise.com/articles/s eattle-children-s-researchers- identify-drug-that-could-suppress- intractable-epilepsy * A STEP TOWARD GENE THERAPY AGAINST INTRACTABLE EPILEPSY By delivering genes for a certain signal substance and its receptor into the brain of test animals with chronic epilepsy, a research group at Lund University in Sweden with colleagues at University of Copenhagen Denmark has succeeded in considerably reducing the number of epileptic seizures among the animals. The test has been designed to as far as possible mimic a future situation involving treatment of human patients. For more information, http://www.eurekalert.org/pub_rele ases/2015-12/lu-ast120315.php * DOCTORS INSERT ELECTRODES INTO CHILD'S BRAIN TO MAP LESION CAUSING EPILEPSY IN QUEENSLAND-FIRST SURGERY New powerful MRI technology has helped Brisbane doctors remove the cause of a four-year-old girl's severe epilepsy, allowing her to head home to her family in C harters Towers in northern Queensland. The technology showed doctors a tiny lesion, dangerously close to the language and motor areas of her brain, was causing the problem. Special electrodes were inserted into the brain to map the lesion's exact location and the surgeon safely removed it. It was the first time it has been performed on a child in Queensland. For more information, http://www.abc.net.au/news/2015- 12-11/special-electrodes-childs- brain-queensland-surgery- epilepsy/7022670 * A NEW DIET PROVIDES HOPE FOR TREATING PATIENTS WITH DRUG-RESISTANT EPILEPSY Scientists from Royal Holloway, University of London and UCL have identified how a specific diet can be used to help treat patients with uncontrolled epilepsy. The findings reveal how the ketogenic diet acts to block seizures in patients with drug-resistant epilepsy. The research team have identified a specific fatty acid, decanoic acid, provided in the MCT (medium chain triglyceride, a chemical containing three fatty acids) ketogenic diet that has potent anti- epileptic effects. The diet comprises of high levels of fat and low levels of carbohydrate- containing foods. For more information, http://medicalxpress.com/news/201 5-11-diet-patients-drug-resistant- epilepsy.html * NEWS & TRENDS

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