Innovations In Clinical Neuroscience

SEP-OCT 2014

A peer-reviewed, evidence-based journal for clinicians in the field of neuroscience

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[ V O L U M E 1 1 , N U M B E R 9 – 1 0 , S E P T E M B E R – O C T O B E R 2 0 1 4 ] Innovations in CLINICAL NEUROSCIENCE 189 reliability and validity. Schizophr Res. 2003;63:161–170. 3. Kroenke K, Spitzer RL, Williams JB. The PHQ-9. J Gen Intern Med. 2009;16(9):606–613. 4. Montgomery SA, Åsberg M. A new depression scale designed to be sensitive to change. Br J Psychiatry. 1979;134:382–389. 5. Posner K., Brown GK, Stanley B et al. The Columbia–Suicide Severity Rating Scale: initial validity and internal consistency findings from three multisite studies with adolescents and adults. Am J Psychiatry. 2011;168:1266–1277. 6. United States Food and Drug Administration, United States Department of Health and Human Services. Guidance for Industry: Suicidality: Prospective Assessment of Occurrence in Clinical Trials, Draft Guidance. September 2010. https://www.federalregister.gov/artic les/2010/09/09/2010-22404/draft- guidance-for-industry-on- suicidality-prospective-assessment- of-occurrence-in-clinical-trials. Accessed October 1, 2014. 7. United States Food and Drug Administration, United States Department of Health and Human Services. Guidance for Industry: Suicidality: Prospective Assessment of Occurrence in Clinical Trials, Draft Guidance. August 2012. Revision 1. http://www.fda.gov/downloads/Drug s/Guidances/UCM225130.pdf. Accessed October 1, 2014. 8. Columbia University Psychiatry Department. What we really know about suicide and medications [video]. March 28th, 2012; 54:32 minutes into the video. Available at: http://www.veomed.com/ va041172402012. Accessed January 2014. 9. Grand Rounds 2011 [video]. Child Center of New York University (NYULMC). October 28, 2011. See at 48:20 minutes. Accessed online November 20, 2012. Available on request from nicole.aujero@nyumc.org. 10. Posner K. C-CASA and C-SSRS in CNS clinical trials: development and implementation. Presentation at the IOM Workshop on CNS Clinical Trials: Suicidality and Data Collection. Washington, DC: June 16, 2009. 11. Posner K. Suicide risk assessment and the Columbia Suicide Severity Rating Scale (C–SSRS): improved precision with reduced burden. http://www.google.com/url?sa=t&rct =j&q=&esrc=s&source=web&cd=2& ved=0CC0QFjAB&url=http%3A%2F %2Fwww.commondataelements.nin ds.nih.gov%2Fdoc%2FCSSRS%2520 Additional%2520Information.pdf&ei =JPr_Ut2UKZTGkQfct4D4AQ&usg= AFQjCNE7nBFxbvO0Mcgsg3zr2sp Mhvck9g&bvm=bv.61535280,d.eW0 &cad=rja. Accessed October 1, 2014. 12. Suicide: a major public health crisis—a Firestorm webinar featuring Dr. Kelly Posner [video]. June 28, 2013. http://www.youtube. com/watch?v=fYqcIt-Ul6Q. Accessed October 1, 2014. 13. Posner K. On the road to prevention: using the Columbia- Suicide Severity Rating Scale to increase precision and redirect scarce resources. Depression Center. University of Michigan. TABLE 1. Correlation matrix of 5 passive suicidal ideation phenomena and impulsive suicidality PHENOMENA Better off dead Need to be dead Wish you were d ead Wish you could go to sleep and not wake up Wish you were not a live anymore Impulsive suicidality Better off dead 1 Need to be dead -0.052064701 1 Wish you were dead 0.366131761 -0.173015584 1 Wish you could go to sleep and not wake up 0.222650204 -0.232061145 0.045954928 1 Wish you were not alive anymore 0.341020353 -0.064278003 0.514338939 0.041449968 1 Impulsive suicidality -0.117465673 0.799858057 -0.344097647 -0.235960183 -0.159294871 1 Sheehan DV, Giddens JM. Copyright © 2014. All rights reserved. Reproduced with permission of the authors.

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